Study confirms gout treatment mechanism in Korean medicine

Recent research has confirmed the effective treatment mechanism of gout in Korean medicine.

Gout is a common and complex form of arthritis. Known as the “disease of kings”, it is one of the oldest joint diseases known to mankind. Ancient Westerners believed gout to be a “bite of the devil”, while modern medical research has found the disease to be caused by the high level of uric acid (urate) in the human body, which is deposited in the joints. and surrounding tissues.

Drugs used in modern medicine to treat gout often have unwanted side effects such as damage to heart, liver and kidney function, while Korean and Chinese doctors treat the disease with purely natural Korean (Chinese) drugs, associated to acupuncture since ancient times. The method they used was found to be very effective, with few side effects.

A research team led by Dr. Lee Junho and Yang Gap-sik, professor of Korean medicine at Wooseok University, announced in April that they discovered the mechanism of treating gout with plant extracts through animal experiments.

For five years, the research team has been studying the mechanism by which Korean medicine extracts are effective in the treatment of gout by regulating the emergence of the inflammatory regulatory complex. As part of the innate immune system, the inflammatory regulatory complex is a protein complex that recognizes danger signals in cells and activates inflammatory responses.

Researchers have confirmed that traditional Korean medicines such as wild chrysanthemum, kiwi, red ginseng, polygonum cuspidatum root, shiny privet fruit and nidus vespae are effective in treating gout.

Lee said this study “provides a scientific basis for the design of clinical trials” in which Korean drugs regulate the emergence of the “inflammatory regulatory complex.”

The research papertitled “Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout,” was published in March in Frontiers in Pharmacology, an SCI-indexed journal.

This is not the first time that a study on the effectiveness of Korean medicine in the treatment of gout has been published in an internationally recognized journal. In 2020, Yang and his research team published an article in the journal Nature Reviews Rheumatology, which for the first time proved the mechanism of treatment of gout by the Korean medical mosquito Wormwood.

The research team found that beta-carotene, which is rich in artemisinin, reduces puffiness and inhibits the production of inflammatory cytokines (signaling substances that control and stimulate the human body’s defense system).

The study showed that β-carotene binds directly to ASC proteins, an important link that forms the inflammatory regulatory complex that induces gout, blocking the formation of the complex.

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